Salem, Illinois...In the Heart of It All!
Here are easy driving directions from virtually every direction...

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From the North:

From Chicago...
I-57 South to Exit 116. 

Approximate Drive Time: 4.5 hours from Chicago; 45 minutes From Effingham.

From Indianapolis...
I-70 West to I-57 South to Exit 116. 

Approximate Drive Time: 3.25 hours from Indianapolis; 45 minutes from Effingham.

From the South:

From Louisville, KY/Evansville, IN...
I-64 West to I-57 North to Exit 116.

Approximate Drive Time: 3.25 hours from Louisville, KY; 2 hours from Evansville, IN; 25 minutes from Mt. Vernon, IL.

From Paducah, KY/Nashville, TN...
I-24 West to I-57 North to Exit 116.

Approximate Drive Time: 3.25 hours from Paducah, KY; 1.5 hours from Marion, IL; 25 minutes from Mt. Vernon, IL.

From Cairo, IL/Memphis, TN...
I-57 North to Exit 116.

Approximate Drive Time: 2.25 hours from Cairo, IL; 5.5 hours from Memphis, TN

From the West (St. Louis Area):

Fastest...
I-64 East to I-57 North to Exit 116.

Shortest...
I-64 West to Exit 20 (U.S. Route 50 Carlyle).  Follow U.S. Route 50 through Lebanon, Carlyle, Sandoval, Odin and on to Salem.

Approximate Drive Time: 1.5 hours from St. Louis.

From the East:

From Vincennes, IN...
U.S. Route 50 West to Salem. 

Approximate Drive Time: 1.5 hours.

Information obtained is accurate as of February 3, 2003.  Please consult current Illinois State map for up-to-date driving directions, estimated drive times, and Interstate/Road names.